The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
50 kDa Nuclear polyadenylated RNA binding protein
50 kDa nuclear polyadenylated RNA-binding protein
Bruno like 2
bruno like protein 2
Bruno-like protein 2
CELF1 CUGBP, Elav like family member 1
CUG BP and ETR 3 like factor 1
CUG RNA binding protein
CUG triplet repeat RNA binding protein 1
CUG triplet repeat RNA-binding protein 1
CUG-BP- and ETR-3-like factor 1
CUGBP and ETR3 like factor 1
CUGBP Elav like family member 1
CUGBP Elav-like family member 1
Cytidine uridine guanosine binding protein 1
Deadenylation factor CUG BP
Deadenylation factor CUG-BP
Deadenylation factor CUGBP
EDEN BP homolog
embryo deadenylation element binding protein
embryo deadenylation element binding protein homolog
Embryo deadenylation element-binding protein homolog
Nuclear polyadenylated RNA binding protein
Nuclear polyadenylated RNA binding protein 50 kD
RNA binding protein BRUNOL 2
RNA binding protein BRUNOL2
RNA-binding protein BRUNOL-2
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.
Belongs to the CELF/BRUNOL family. Contains 3 RRM (RNA recognition motif) domains.
Phosphorylated. Its phosphorylation status increases in senescent cells.
Nucleus. Cytoplasm. RNA-binding activity is detected in both nuclear and cytoplasmic compartments.