Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGL KGRLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAA GSDGTELFDQVHRWVNYESMLKECLVGRMAIKPAVLKDYREEEKKVLNGM LPKSQVTDTLAKEGPSYPSYDWFQTDSLVTIAIYTKQKDINLDSIIVDHQ NDSFRAETIIKDCLYLIHIGLSHEVQEDFSVRVVESVGKIEIVLQKKENT SWDFLGHPLKNHNSLIPRKDTGLYYRKCQLISKEDVTHDTRLFCLMLPPS THLQVPIGQHVYLKLPITGTEIVKPYTPVSGSLLSEFKEPVLPNNKYIYF LIKIYPTGLFTPELDRLQIGDFVSVSSPEGNFKISKFQELEDLFLLAAGT GFTPMVKILNYALTDIPSLRKVKLMFFNKTEDDIIWRSQLEKLAFKDKRL DVEFVLSAPISEWNGKQGHISPALLSEFLKRNLDKSKVLVCICGPVPFTE QGVRLLHDLNFSKNEIHSFTA
    • Amino acids

      1 to 521
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab162439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.

     This product was previously labelled as CYB5R4

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • b5+b5R
    • b5b5r
    • C79736
    • cb5/cb5R
    • Cb5cb5r
    • Cyb5r4
    • Cytochrome b type NAD(P)H oxidoreductase
    • Cytochrome b5 reductase 4
    • dJ676J13.1
    • Flavohemoprotein b5+b5R
    • Flavohemoprotein b5/b5R
    • N terminal cytochrome b5 and cytochrome b5 oxidoreductase domain containing protein
    • N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
    • NADPH cytochrome B5 oxidoreductase
    • NB5R4_HUMAN
    • NCB5OR
    • RP4 676J13.1
    see all
  • Function

    NADH-cytochrome b5 reductase involved in endolasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
  • Tissue specificity

    Widely expressed.
  • Sequence similarities

    Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    Contains 1 CS domain.
    Contains 1 cytochrome b5 heme-binding domain.
    Contains 1 FAD-binding FR-type domain.
  • Cellular localization

    Endoplasmic reticulum. Soluble protein.
  • Information by UniProt

Images

  • ab162439 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab162439 has not yet been referenced specifically in any publications.

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