Product nameRecombinant Human Cyclin C protein
See all Cyclin C proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
Our Abpromise guarantee covers the use of ab59893 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity> 90 % SDS-PAGE.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Constituents: 0.5% Triton-X-100, 0.9375% Potassium chloride, 0.595% HEPES, 50% Glycerol
FunctionComponent of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Tissue specificityHighest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Sequence similaritiesBelongs to the cyclin family. Cyclin C subfamily.
Contains 1 cyclin N-terminal domain.
- Information by UniProt
ab59893 has not yet been referenced specifically in any publications.