Description

  • Product name

    Recombinant Human Cyclin H/p34 protein
    See all Cyclin H/p34 proteins and peptides
  • Purity

    > 90 % SDS-PAGE.
    ab95351 is purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP HEEMTLCKYY EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV SSPQFVGNLR ESPLGQEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI LENPEILRKT ADDFLNRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE NRTCLSQLLD IMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRKGYEDD DYVSKKSKHE EEEWTDDDLV ESL

Specifications

Our Abpromise guarantee covers the use of ab95351 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

     This product was previously labelled as Cyclin H

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.0308% DTT, 0.316% Tris HCl, 0.0584% EDTA, 30% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • 6330408H09Rik
    • AI661354
    • AV102684
    • AW538719
    • CAK
    • CAK complex subunit
    • ccnh
    • CCNH_HUMAN
    • CDK activating kinase
    • CDK activating kinase complex subunit
    • Cyclin dependent kinase activating kinase
    • cyclin dependent kinase activating kinase complex subunit
    • Cyclin H
    • Cyclin-H
    • CyclinH
    • MO15 associated protein
    • MO15-associated protein
    • p34
    • p36
    • p37
    see all
  • Function

    Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
  • Sequence similarities

    Belongs to the cyclin family. Cyclin C subfamily.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab95351 at approximately 40 kDa (3 µg).

References

ab95351 has not yet been referenced specifically in any publications.

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