Description

  • Product name

    Recombinant Human Cyclophilin B protein
    See all Cyclophilin B proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    HEK 293 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      DEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGE KGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHY GPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVE STKTDSRDKPLKDVIIADCGKIEVEKPFA
    • Predicted molecular weight

      21 kDa including tags
    • Amino acids

      34 to 212
    • Tags

      His tag C-Terminus
    • Additional sequence information

      Accession NP_000933.

Specifications

Our Abpromise guarantee covers the use of ab179977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -20°C or -80°C. Reconstitute for long term storage.

    pH: 7.40
    Constituents: 95% PBS, 5% Trehalose

General Info

  • Alternative names

    • AA408962
    • AA553318
    • AI844835
    • Cphn 2
    • Cphn2
    • Cyclophilin B
    • Cyclophilin like protein
    • CyP 20b
    • CYP S1
    • CYP-S1
    • CYPB
    • EC 5.2.1.8
    • MGC14109
    • MGC2224
    • OI9
    • peptidyl prolyl cis trans isomerase B
    • Peptidyl prolyl cis trans isomerase B precursor
    • Peptidyl-prolyl cis-trans isomerase B
    • Peptidylprolyl isomerase B
    • peptidylprolyl isomerase B (cyclophilin B)
    • PPIase
    • PPIase B
    • Ppib
    • PPIB_HUMAN
    • Rotamase
    • Rotamase B
    • S cyclophilin
    • S-cyclophilin
    • SCYLP
    see all
  • Function

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • Involvement in disease

    Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9) [MIM:259440]. OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.
  • Sequence similarities

    Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
    Contains 1 PPIase cyclophilin-type domain.
  • Cellular localization

    Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

Images

  • SDS-PAGE analysis of reduced ab179977 stained overnight with Coomassie Blue.

    ab179977 migrates as 22 kDa due to glycosylation.

References

ab179977 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab179977.
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