Recombinant Human CYP4V2 protein (ab166203)
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Overview
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Product nameRecombinant Human CYP4V2 protein
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Protein lengthFull length protein
Description
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NatureRecombinant
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SourceWheat germ
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Amino Acid Sequence
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SpeciesHuman
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SequenceMAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPI PTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMV ALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKML TPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDII CETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKE GWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFL DLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPE VQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFAR SVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQ GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELG LEGQLILRPSNGIWIKLKRRNADER
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Amino acids1 to 525
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Tagsproprietary tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab166203 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
ELISA
Western blot
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FormLiquid
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Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- BCD
- CP4V2_HUMAN
- CYP4AH1
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FunctionCatalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). May have a role in fatty acid and steroid metabolism in the eye.
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Tissue specificityBroadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes.
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Involvement in diseaseBietti crystalline corneoretinal dystrophy (BCD) [MIM:210370]: An autosomal recessive ocular disease characterized by retinal degeneration and marginal corneal dystrophy. Typical features include multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most patients have similar crystals at the corneoscleral limbus. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, they develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Sequence similaritiesBelongs to the cytochrome P450 family.
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Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
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References
ab166203 has not yet been referenced specifically in any publications.