Product nameRecombinant Human Cytochrome C protein
See all Cytochrome C proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceMGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYT AANKNKGIIWGEDTL MEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNELEHHHHHH
Molecular weight11 kDa
Amino acids1 to 105
TagsHis tag C-Terminus
- Anti-Cytochrome C antibody [37BA11] (ab110325)
- Anti-Cytochrome C antibody [EPR1327] (ab133504)
- Anti-Cytochrome C antibody [7H8.2C12] (ab13575)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-Cytochrome C antibody (ab18738)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-Cytochrome C antibody [2CYTC-199] (ab50050)
- Anti-Cytochrome C antibody [EP1326-80-5] (ab76107)
- Anti-Cytochrome C antibody [EP1326-80-5-4] (ab76237)
- Anti-Cytochrome C antibody (ab90529)
- Anti-6X His tag® antibody (ab9108)
Our Abpromise guarantee covers the use of ab172817 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 1.000 Eu/µg
Purity>95% by SDS-PAGE .
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 0.24% Tris, 20% Glycerol, 0.88% Sodium chloride
Supplied as a 0.2 µM filtered solution.
FunctionElectron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Involvement in diseaseDefects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
Sequence similaritiesBelongs to the cytochrome c family.
modificationsBinds 1 heme group per subunit.
Cellular localizationMitochondrion matrix.
- Information by UniProt
ab172817 has not yet been referenced specifically in any publications.