Description

  • Product name

    Recombinant human DCLK2 protein
  • Biological activity

    The Specific activity of ab85758 was determined to be 94 nmol/min/mg.
  • Expression system

    Baculovirus infected Sf9 cells
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Amino acids

      1 to 690

Associated products

Specifications

Our Abpromise guarantee covers the use of ab85758 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    ab204861 (Hsp27 peptide) can be utilized as a substrate for assessing kinase activity

    Previously labelled as DCAMKL2.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.0038% EGTA, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • CaMK-like CREB regulatory kinase 2
    • CL2
    • CLICK-II
    • CLICK2
    • DCAMK L2
    • DCAMKL 2
    • DCAMKL2
    • DCDC 3
    • DCDC 3B
    • DCDC3
    • DCDC3B
    • DCK 2
    • DCK2
    • DCLK 2
    • Dclk2
    • DCLK2_HUMAN
    • DKFZp761I032
    • Doublecortin and CaM kinase like 2
    • Doublecortin domain-containing protein 3B
    • Doublecortin like and CAM kinase like 2
    • Doublecortin like kinase 2
    • Doublecortin-like and CAM kinase-like 2
    • Doublecortin-like kinase 2
    • MGC45428
    • Serine/threonine protein kinase DCLK2
    • Serine/threonine-protein kinase DCLK2
    see all
  • Function

    Protein kinase with a significantly reduced Ca2+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 2 doublecortin domains.
    Contains 1 protein kinase domain.
  • Domain

    The doublecortin domains are involved in the colocalization with microtubules.
  • Cellular localization

    Cytoplasm > cytoskeleton. Colocalizes with microtubules.
  • Information by UniProt

Images

  • SDS PAGE analysis of ab85758
  • The Specific activity of ab85758 was determined to be 94 nmol/min/mg.
  • SDS-PAGE showing ab85758 at approximately 105kDa.

References

ab85758 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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