Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      STQLSNLGSTETLEEMPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAVV GLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSETLGVPSAAHHSVQ
    • Amino acids

      186 to 285
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163234 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • DCP1 decapping enzyme homolog A
    • Dcp1a
    • DCP1A_HUMAN
    • Decapping enzyme hDcp1a
    • Decapping mRNA 1A
    • HSA275986
    • mRNA decapping enzyme 1A
    • mRNA-decapping enzyme 1A
    • Nbla00360
    • Putative protein product of Nbla00360
    • Smad4 interacting transcriptional co activator
    • Smad4-interacting transcriptional co-activator
    • Smad4-interacting transcriptional co-activator
    • SMAD4IP1
    • SMIF
    • Transcription factor SMIF
    see all
  • Function

    Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
  • Tissue specificity

    Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
  • Sequence similarities

    Belongs to the DCP1 family.
  • Cellular localization

    Cytoplasm > P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.
  • Information by UniProt

Images

  • ab163234 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163234 has not yet been referenced specifically in any publications.

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