Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
      O95407
    • Species
      Human
    • Sequence
      MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE GWGPTP
    • Molecular weight
      58 kDa including tags
    • Amino acids
      1 to 246

Associated products

Specifications

Our Abpromise guarantee covers the use of ab157279 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    ab157279 binds Human LIGHT. Does not bind Human FasL.
  • Applications

    Functional Studies

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    >95% by SDS-PAGE .

  • Form
    Lyophilised
  • Additional notes
    ab157279 binds Human LIGHT. Does not bind Human FasL.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituent: 99% PBS

  • Reconstitution
    Reconstitute with 50µl sterile water to a concentration of 1 mg/ml. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

General Info

  • Alternative names
    • DcR3
    • Decoy receptor 3
    • Decoy receptor for Fas ligand
    • DJ583P15.1.1
    • M68
    • M68E
    • OTTHUMP00000031583
    • TNF6B_HUMAN
    • TNFRSF6B
    • TR6
    • Tumor necrosis factor receptor superfamily member 6B
    • Tumor necrosis factor receptor superfamily member 6b decoy
    • UNQ186/PRO212
    see all
  • Function
    Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis.
  • Tissue specificity
    Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
  • Sequence similarities
    Contains 4 TNFR-Cys repeats.
  • Cellular localization
    Secreted.
  • Information by UniProt

Images

  • Functional Studies - DcR3 protein (Fc Chimera) (ab157279)
    Functional Studies - DcR3 protein (Fc Chimera) (ab157279)
    ELISA analysis of ab157279.

References

ab157279 has not yet been referenced specifically in any publications.

Publishing research using ab157279? Please let us know so that we can cite the reference in this datasheet.

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