Overview

  • Product name

    Recombinant Human DCTN1/p150-glued protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLH VAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKS PSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSA FLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS
    • Molecular weight

      48 kDa including tags
    • Amino acids

      1082 to 1278

Specifications

Our Abpromise guarantee covers the use of ab132084 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.

    Previously labelled as DCTN1. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • 150 kDa dynein associated polypeptide
    • 150 kDa dynein-associated polypeptide
    • DAP 150
    • DAP-150
    • DAP150
    • DCTN 1
    • DCTN1
    • DCTN1_HUMAN
    • DP 150
    • DP-150
    • DP150
    • Dynactin 1
    • Dynactin 1 (p150 Glued (Drosophila) homolog)
    • Dynactin 1 (p150 glued homolog Drosophila)
    • Dynactin subunit 1
    • Dynactin1
    • HMN7B
    • p135
    • p150 glued
    • p150 Glued (Drosophila) homolog
    • p150 glued homolog
    • p150(GLUED) DROSOPHILA HOMOLOG OF
    • p150-glued
    • p150glued
    see all
  • Function

    Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
  • Tissue specificity

    Brain.
  • Involvement in disease

    Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B) [MIM:607641]; also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
    Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
    Defects in DCTN1 are the cause of Perry syndrome (PERRYS) [MIM:168605]; also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.
  • Sequence similarities

    Belongs to the dynactin 150 kDa subunit family.
    Contains 1 CAP-Gly domain.
  • Post-translational
    modifications

    Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab132084 stained with Coomassie Blue.

References

ab132084 has not yet been referenced specifically in any publications.

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