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Recombinant human DCXR protein (Active) (ab219429)

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SDS-PAGE - Recombinant human DCXR protein (Active) (ab219429)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Active: Yes
    • Tags: His tag N-Terminus
    • Suitable for: MS, Functional Studies, SDS-PAGE

    Description

    • Product name

      Recombinant human DCXR protein (Active)
      See all DCXR proteins and peptides
    • Biological activity

      Specific activity is > 1,800 pmol/min/ug and is defined as the amount of enzyme that oxidize 1 pmole of xylitol to L-xylulose per minute at pH 10.0 at 37ºC.

    • Purity

      > 95 % SDS-PAGE.
      ab219429 was purified using conventional chromatography techniques.
    • Expression system

      Escherichia coli
    • Accession

      Q7Z4W1
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MGSSHHHHHHSSGLVPRGSHMELFLAGRRVLVTGAGKGIGRGTVQALHAT GARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLL VNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGA IVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT TGSTLPVEGGFWAC
      • Predicted molecular weight

        28 kDa including tags
      • Amino acids

        1 to 244
      • Tags

        His tag N-Terminus
      • Additional sequence information

        NP_057370.

    Associated products

    • Related Products

      • Anti-DCXR antibody (ab154290)
      • Anti-6X His tag® antibody [HIS.H8] (ab18184)
      • Anti-DCXR antibody (ab191369)
      • Anti-6X His tag® antibody [4D11] (ab5000)
      • Anti-6X His tag® antibody (ab9108)

    Specifications

    Our Abpromise guarantee covers the use of ab219429 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Mass Spectrometry

      Functional Studies

      SDS-PAGE

    • Mass spectrometry

      MALDI-TOF
    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% DTT, 0.29% Sodium chloride

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    General Info

    • Alternative names

      • Carbonyl reductase 2
      • Carbonyl reductase II
      • DCR
      • Dcxr
      • DCXR_HUMAN
      • Dicarbonyl and L xylulose reductase
      • Dicarbonyl L xylulose reductase
      • Dicarbonyl/ L xylulose reductase
      • Dicarbonyl/L-xylulose reductase
      • HCR2
      • HCRII
      • Human carbonyl reductase 2
      • kiDCR
      • Kidney dicarbonyl reductase
      • L xylulose reductase
      • L-xylulose reductase
      • P34H
      • PNTSU
      • SDR20C1
      • Short chain dehydrogenase/reductase family 20C member 1
      • Sperm surface protein P34H
      • XR
      see all
    • Function

      Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
    • Tissue specificity

      Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
    • Involvement in disease

      Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
    • Sequence similarities

      Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    • Cellular localization

      Membrane. Probably recruited to membranes via an interaction with phosphatidylinositol.
    • Target information above from: UniProt accession Q7Z4W1 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant human DCXR protein (Active) (ab219429)
      SDS-PAGE - Recombinant human DCXR protein (Active) (ab219429)

      15% SDS-PAGE analysis of 3 μg ab219429.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab219429? Please let us know so that we can cite the reference in this datasheet.

    ab219429 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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