Recombinant Human Dectin-1 protein (ab163849)
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Overview
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Product nameRecombinant Human Dectin-1 protein
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Protein lengthFull length protein
Description
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NatureRecombinant
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SourceWheat germ
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Amino Acid Sequence
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SpeciesHuman
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SequenceMEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWRLIAVIL GILCLVILVIAVVLGTMAGFKAVEFKG
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Amino acids1 to 77
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Tagsproprietary tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab163849 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
ELISA
Western blot
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FormLiquid
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Additional notesProtein concentration is above or equal to 0.05 mg/ml.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- Beta GR
- Beta-glucan receptor
- BGR
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FunctionLectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.
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Tissue specificityHighly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
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Involvement in diseaseDefects in CLEC7A may be a cause of familial candidiasis type 4 (CANDF4) [MIM:613108]. It is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
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Sequence similaritiesContains 1 C-type lectin domain.
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Post-translational
modificationsPhosphorylated on tyrosine residues in response to glucan binding. -
Cellular localizationCytoplasm and Cell membrane.
- Information by UniProt
Images
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SDS-PAGE - Recombinant Human Dectin-1 protein (ab163849)ab163849 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab163849 has not yet been referenced specifically in any publications.
