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    recombinant-human-dectin-1-protein-ab163849.pdf

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Immunology Innate Immunity Macrophage / Inflamm.
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Recombinant Human Dectin-1 protein (ab163849)

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SDS-PAGE - Recombinant Human Dectin-1 protein (ab163849)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human Dectin-1 protein
      See all Dectin-1 proteins and peptides
    • Expression system

      Wheat germ
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWRLIAVIL GILCLVILVIAVVLGTMAGFKAVEFKG
      • Amino acids

        1 to 77
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab163849 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • Beta GR
      • Beta-glucan receptor
      • BGR
      • C type calcium dependent carbohydrate recognition domain lectin superfamily member 12
      • C type lectin domain family 7 member a
      • C-type lectin domain family 7 member A
      • C-type lectin superfamily member 12
      • CANDF4
      • CLC7A_HUMAN
      • CLEC7A
      • CLEC7A protein
      • Clecsf12
      • DC-associated C-type lectin 1
      • Dectin 1
      • DECTIN 1 receptor
      • Dectin-1
      • Dectin1
      • Dendritic cell associated C type lectin 1
      • Dendritic cell-associated C-type lectin 1
      • Lectin like receptor 1
      • Putative transmembrane protein dectin 1
      see all
    • Function

      Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.
    • Tissue specificity

      Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
    • Involvement in disease

      Defects in CLEC7A may be a cause of familial candidiasis type 4 (CANDF4) [MIM:613108]. It is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
    • Sequence similarities

      Contains 1 C-type lectin domain.
    • Post-translational
      modifications

      Phosphorylated on tyrosine residues in response to glucan binding.
    • Cellular localization

      Cytoplasm and Cell membrane.
    • Target information above from: UniProt accession Q9BXN2 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Dectin-1 protein (ab163849)
      SDS-PAGE - Recombinant Human Dectin-1 protein (ab163849)
      ab163849 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab163849? Please let us know so that we can cite the reference in this datasheet.

    ab163849 has not yet been referenced specifically in any publications.

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