Recombinant Human DECTIN 2 protein (ab157028)
- Datasheet
- References
- Protocols
Overview
-
Product nameRecombinant Human DECTIN 2 protein
-
Protein lengthProtein fragment
Description
-
NatureRecombinant
-
SourceHEK 293 cells
-
Amino Acid Sequence
-
Accession
-
SpeciesHuman
-
SequenceIMDQPSRRLYELHTYHSSLTCFSEGTMVSEKMWGCCPNHWKSFGSSCYLI STKENFWSTS EQNCVQMGAHLVVINTEAEQNFITQQLNESLSYFLGLS DPQGNGKWQWIDDTPFSQNVRF WHPHEPNLPEERCVSIVYWNPSKWGW NDVFCDSKHNSICEMKKIYL
-
Molecular weight55 kDa including tags
-
Amino acids44 to 209
-
Associated products
-
Related Products
Specifications
Our Abpromise guarantee covers the use of ab157028 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Applications
SDS-PAGE
-
Endotoxin level< 0.100 Eu/µg
-
Purity>95% by SDS-PAGE .
-
FormLyophilised
-
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped at 4°C. Store at -20°C.
Constituent: 100% PBS
-
ReconstitutionReconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
General Info
-
Alternative names
- C type lectin domain family 6 member A
- C type lectin superfamily member 10
- C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
see all -
FunctionBinds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.
-
Tissue specificityExpressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
-
Sequence similaritiesContains 1 C-type lectin domain.
-
DomainA short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for association with Fc receptor gamma chain.
-
Cellular localizationMembrane.
- Information by UniProt
Datasheets and documents
References
ab157028 has not yet been referenced specifically in any publications.
