Recombinant Human DECTIN 2 protein (ab157028)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 0.100 Eu/µg
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Human DECTIN 2 protein
See all DECTIN 2 proteins and peptides -
Purity
> 95 % SDS-PAGE. -
Endotoxin level
< 0.100 Eu/µg -
Expression system
HEK 293 cells -
Accession
-
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
IMDQPSRRLYELHTYHSSLTCFSEGTMVSEKMWGCCPNHWKSFGSSCYLI STKENFWSTS EQNCVQMGAHLVVINTEAEQNFITQQLNESLSYFLGLS DPQGNGKWQWIDDTPFSQNVRF WHPHEPNLPEERCVSIVYWNPSKWGW NDVFCDSKHNSICEMKKIYL -
Predicted molecular weight
55 kDa including tags -
Amino acids
44 to 209
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab157028 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C.
Constituent: 100% PBS
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ReconstitutionReconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
General Info
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Alternative names
- C type lectin domain family 6 member A
- C type lectin superfamily member 10
- C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
see all -
Function
Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway. -
Tissue specificity
Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids. -
Sequence similarities
Contains 1 C-type lectin domain. -
Domain
A short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for association with Fc receptor gamma chain. -
Cellular localization
Membrane. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab157028 has not yet been referenced specifically in any publications.