Overview

  • Product name

    Recombinant Human DEDD protein (denatured)
  • Protein length

    Full length protein
  • Description

    Recombinant Human DEDD protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MAGLKRRASQ VWPEEHGEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV DVIDDHERGL IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY VTLKRRRAVC PDLVDKYLEE TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP VVCCPTSGPQ MCSKRPARGR ATLGSQRKRR KSVTPDPKEK QTCDIRLRVR AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD LGSIICDIKF SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED YELGRQKLLR NLMLQALP
    • Molecular weight

      39 kDa including tags
    • Amino acids

      1 to 318
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab140059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 85 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • CASP8IP1
    • Death effector domain containing
    • Death effector domain containing protein
    • Death effector domain containing testicular molecule
    • Death effector domain-containing protein
    • Death effector domain-containing testicular molecule
    • dedD
    • DEDD 1
    • DEDD_HUMAN
    • DEDD1
    • DEDPro 1
    • DEDPro1
    • DEFT
    • FLDED 1
    • FLDED-1
    • FLDED1
    • KE 05
    • KE05
    • OTTHUMP00000031822
    see all
  • Function

    A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.
  • Tissue specificity

    Widely expressed with highest levels in testis.
  • Sequence similarities

    Contains 1 DED (death effector) domain.
  • Post-translational
    modifications

    Exists predominantly in a mono- or diubiquitinated form.
  • Cellular localization

    Cytoplasm. Nucleus > nucleolus. Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab140059 (3µg)

References

ab140059 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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