The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Differentially expressed in FDCP 6 homolog
Differentially expressed in FDCP 6 homologue mouse
Swap70 like adapter of T cells
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP-70 signaling.
Broadly expressed in the immune system and can be detected in T and B-cells.
Contains 1 PH domain.
The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation.
Cytoplasm. Cell membrane. Nucleus. Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.