Description

  • Product name

    Recombinant Human delta 1 Catenin/CAS protein
  • Expression system

    Wheat germ
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      WGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKS DKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNKTLDRSGDLGDMEPL KGTTPLMQKI
    • Predicted molecular weight

      38 kDa including tags
    • Amino acids

      721 to 830

Specifications

Our Abpromise guarantee covers the use of ab114472 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
    ab114472 is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names

    • Cadherin associated Src substrate
    • Cadherin-associated Src substrate
    • CAS
    • Catenin (cadherin associated protein) delta 1
    • Catenin delta
    • Catenin delta 1
    • Catenin delta-1
    • CTND1_HUMAN
    • CTNND
    • CTNND 1
    • CTNND1
    • delta 1 Catenin
    • KIAA0384
    • p120
    • P120 CAS
    • p120 catenin
    • P120 CTN
    • p120(cas)
    • p120(ctn)
    • P120CAS
    • P120CTN
    see all
  • Function

    Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
  • Tissue specificity

    Expressed in vascular endothelium.
  • Sequence similarities

    Belongs to the beta-catenin family.
    Contains 10 ARM repeats.
  • Domain

    A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
  • Post-translational
    modifications

    Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
  • Cellular localization

    Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
  • Information by UniProt

Images

  • ab114472 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab114472 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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