The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 µg/µl.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Deiodinase, iodothyronine, type II
Thyroxine deiodinase, type II
Type 2 DI
Type 2 iodothyronine deiodinase
Type II 5' deiodinase
Type II iodothyronine deiodinase
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain.
Belongs to the iodothyronine deiodinase family.
Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33.