Description

  • Product name

    Recombinant Human DIPP protein
  • Purity

    > 95 % SDS-PAGE.
    Purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR
    • Predicted molecular weight

      22 kDa including tags
    • Amino acids

      1 to 172
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab103915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Additional notes

    Previously labelled as NUDT3. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.077% DTT, 0.316% Tris HCl, 20% Glycerol, 1.16% Sodium chloride

General Info

  • Alternative names

    • 5''''-P1
    • Diadenosine 5' 5''' P1 P6 hexaphosphate hydrolase 1
    • Diadenosine 5''
    • Diphosphoinositol polyphosphate phosphohydrolase
    • Diphosphoinositol polyphosphate phosphohydrolase 1
    • DIPP
    • DIPP 1
    • DIPP-1
    • DIPP1
    • Nucleoside diphosphate linked moiety X motif 3
    • Nucleoside diphosphate-linked moiety X motif 3
    • Nudix (nucleoside diphosphate linked moiety X) type motif 3
    • Nudix motif 3
    • Nudix type motif 3
    • NUDT 3
    • Nudt3
    • NUDT3_HUMAN
    • P6-hexaphosphate hydrolase 1
    see all
  • Function

    Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
  • Tissue specificity

    Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
  • Sequence similarities

    Belongs to the Nudix hydrolase family. DIPP subfamily.
    Contains 1 nudix hydrolase domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab103915 (3 µg).

References

ab103915 has not yet been referenced specifically in any publications.

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