Description

  • Product name

    Recombinant human DKK2 protein
    See all DKK2 proteins and peptides
  • Biological activity

    Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3 E1 cells. The expected ED50 for this effect is 0.5 - 1.0 µg/ml.

  • Purity

    > 95 % SDS-PAGE.
    The purity of ab190999 is greater than 98% by SDS-PAGE gel and HPLC analyses.
  • Endotoxin level

    < 0.100 Eu/µg
  • Expression system

    CHO cells
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      SQIGSSRAKL NSIKSSLGGE TPGQAANRSA GMYQGLAFGG SKKGKNLGQA YPCSSDKECE VGRYCHSPHQ GSSACMVCRR KKKRCHRDGM CCPSTRCNNG ICIPVTESIL TPHIPALDGT RHRDRNHGHY SNHDLGWQNL GRPHTKMSHI KGHEGDPCLR SSDCIEGFCC ARHFWTKICK PVLHQGEVCT KQRKKGSHGL EIFQRCDCAK GLSCKVWKDA TYSSKARLHV CQKI
    • Predicted molecular weight

      26 kDa
    • Amino acids

      26 to 259
    • Additional sequence information

      ab190999 is a glycoprotein.

Specifications

Our Abpromise guarantee covers the use of ab190999 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    Functional Studies

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

    Avoid inhalation. Avoid contact with eyes, skin and clothing.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    For lot specific reconstitution information please contact our Scientific Support Team.

General Info

  • Alternative names

    • Dickkopf 2
    • Dickkopf gene 2
    • Dickkopf homolog 2
    • Dickkopf related protein 2
    • Dickkopf WNT signaling pathway inhibitor 2
    • Dickkopf-2
    • Dickkopf-related protein 2
    • Dickkopf2
    • DKK 2
    • Dkk-2
    • Dkk2
    • DKK2_HUMAN
    • hDkk 2
    • hDkk-2
    • hDkk2
    see all
  • Function

    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • Tissue specificity

    Expressed in heart, brain, skeletal muscle and lung.
  • Sequence similarities

    Belongs to the dickkopf family.
  • Domain

    The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Post-translational
    modifications

    May be proteolytically processed by a furin-like protease.
  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab190999 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab190999.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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