Recombinant human DLL1 protein (Active) (ab245808)

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Key features and details

  • Expression system: HEK 293 cells
  • Active: Yes
  • Suitable for: HPLC, SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant human DLL1 protein (Active)
    See all DLL1 proteins and peptides

  • Biological activity

    Determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP-1. sDLL-1 inhibits the proliferation in THP-1 cells using a concentration of 3.0-5.0 μg/ml.

  • Expression system

    HEK 293 cells

  • Accession

    O00548

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      SGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFFRVCLKHYQASV SPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTFS LIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDL KYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYC TEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQP WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYT GATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCA DGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPP GYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLP ELPPGPAVVDLTEKLEGQGGPF

    • Predicted molecular weight

      56 kDa

    • Amino acids

      22 to 543

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab245808 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      HPLC

      SDS-PAGE

      Functional Studies

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      Constituents: 0.16% Sodium phosphate, 0.87% Sodium chloride

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute in water to 0.1-1.0 mg/ml.

    General Info

    • Alternative names

      • Delta
      • Delta (Drosophila) like 1
      • Delta like 1
      • Delta like 1 (Drosophila)
      • Delta like 1 protein
      • Delta like protein 1
      • Delta like protein 1 precursor
      • Delta, Drosophila, homolog of 1
      • Delta-like protein 1
      • Delta1
      • DL1
      • DLL 1
      • DLL1
      • DLL1_HUMAN
      • Drosophila Delta homolog 1
      • H-Delta-1
      • OTTHUMP00000017690
      see all

    • Function

      Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

    • Tissue specificity

      Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

    • Sequence similarities

      Contains 1 DSL domain.
      Contains 8 EGF-like domains.

    • Post-translational
      modifications

      Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab245808? Please let us know so that we can cite the reference in this datasheet.

    ab245808 has not yet been referenced specifically in any publications.

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