Recombinant Human DLL3 protein (Tagged) (ab226231)

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Description

  • Product name

    Recombinant Human DLL3 protein (Tagged)
    See all DLL3 proteins and peptides

  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    Q9NYJ7

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      AGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFFRVCLKPGLSEEAAESP CALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTFSFIIET WREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRA RCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSP EHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPG PCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGL CVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALR CRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDC RERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASAL PAAPPGLRPGDPQRYL

    • Predicted molecular weight

      65 kDa including tags

    • Amino acids

      27 to 492

    • Tags

      His tag N-Terminus

    • Additional sequence information

      N-terminal 6xHis-SUMO tag.

Specifications

Our Abpromise guarantee covers the use of ab226231 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Constituents: 50% Glycerol, Tris buffer

General Info

  • Alternative names

    • Delta Drosophila like 3
    • Delta like 3 Drosophila
    • Delta like 3 homolog Drosophila
    • Delta like 3 protein
    • Delta like protein 3 precursor
    • Delta-like protein 3
    • Delta3
    • Dll3
    • DLL3_HUMAN
    • Drosophila Delta homolog 3
    • SCDO1
    • SCOD1
    • Spondylocostal dysostosis autosomal recessive
    see all

  • Function

    Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.

  • Involvement in disease

    Spondylocostal dysostosis 1

  • Sequence similarities

    Contains 1 DSL domain.
    Contains 6 EGF-like domains.

  • Domain

    The DSL domain is required for binding to the Notch receptor.

  • Post-translational
    modifications

    Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human DLL3 protein (Tagged) (ab226231)
    SDS-PAGE - Recombinant Human DLL3 protein (Tagged) (ab226231)

    (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

References

ab226231 has not yet been referenced specifically in any publications.

Publishing research using ab226231? Please let us know so that we can cite the reference in this datasheet.

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