Overview

  • Product name

    Recombinant Human DNAI2 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIMPNPELAEQFVERNPVDTG IQCSISMSEHEANSERFEMETRGVNHVEGGWPKDVNPLELEQTIRFRKKV EKDENYVNAIMQLGSIMEHCIKQNNAIDIYEEYFNDEEAMEVMEEDPSAK TINVFRDPQEIKRAATHLSWHPDGNRKLAVAYSCLDFQRAPVGMSSDSYI WDLENPNKPELALKPSSPLVTLEFNPKDSHVLLGGCYNGQIACWDTRKGS LVAELSTIESSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKMSEP TEVVILDITKKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAK TSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSI MWTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCDPTLSLKD NGCLIACGSQLGTTTLLEVSPGLSTLQRNEKNVASSMFERETRREKILEA RHREMRLKEKGKAEGRDEEQTDEELAVDLEALVSKAEEEFFDIIFTELKK KEADAIKLTPVPQQPSPEEDQVVEEGEEAAGEEGDEEVEEDLA
    • Amino acids

      1 to 593
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163843 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.

     This product was previously labelled as Dynein intermediate chain 2

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • axonemal
    • Axonemal dynein intermediate chain 2
    • CILD9
    • DNAI 2
    • Dnai2
    • DNAI2_HUMAN
    • Dynein axonemal intermediate chain 2
    • Dynein axonemal intermediate polypeptide 2
    • Dynein intermediate chain 2
    • Dynein intermediate chain 2 axonemal
    see all
  • Function

    Part of the dynein complex of respiratory cilia.
  • Tissue specificity

    Highly expressed in trachea and testis.
  • Involvement in disease

    Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • Sequence similarities

    Belongs to the dynein intermediate chain family.
    Contains 5 WD repeats.
  • Cellular localization

    Cytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt

Images

  • ab163843 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

This product has been referenced in:

  • Calderilla-Barbosa L  et al. Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking. J Cell Sci 127:4052-63 (2014). Read more (PubMed: 25015291) »
See 1 Publication for this product

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