Description

  • Product name

    Recombinant Human Dnmt3L protein (BSA and azide free)
    See all Dnmt3L proteins and peptides
  • Purity

    > 90 % SDS-PAGE.
    ab180335 was purified using conventional chromatography.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSEFMAAIP ALDPEAEPSM DVILVGSSEL SSSVSPGTGR DLIAYEVKAN QRNIEDICIC CGSLQVHTQH PLFEGGICAP CKDKFLDALF LYDDDGYQSY CSICCSGETL LICGNPDCTR CYCFECVDSL VGPGTSGKVH AMSNWVCYLC LPSSRSGLLQ RRRKWRSQLK AFYDRESENP LEMFETVPVW RRQPVRVLSL FEDIKKELTS LGFLESGSDP GQLKHVVDVT DTVRKDVEEW GPFDLVYGAT PPLGHTCDRP PSWYLFQFHR LLQYARPKPG SPRPFFWMFV DNLVLNKEDL DVASRFLEME PVTIPDVHGG SLQNAVRVWS NIPAIRSRHW ALVSEEELSL LAQNKQSSKL AAKWPTKLVK NCFLPLREYF KYFSTELTSS L
    • Predicted molecular weight

      46 kDa including tags
    • Amino acids

      1 to 386
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NP_787063

Specifications

Our Abpromise guarantee covers the use of ab180335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8
    Constituents: 0.32% Tris HCl, 0.88% Sodium chloride, 10% Glycerol, 0.02% DTT

General Info

  • Alternative names

    • Cytosine 5 methyltransferase 3 like protein
    • DNA (cytosine 5 ) methyltransferase 3 like
    • DNA (cytosine-5)-methyltransferase 3-like
    • DNA cytosine 5 methyltransferase 3 like protein
    • DNA methyltransferase 3 like protein
    • DNM3L_HUMAN
    • Dnmt 3L
    • Dnmt3l
    • Human cytosine 5 methyltransferase 3 like protein
    • MGC1090
    see all
  • Function

    Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
  • Tissue specificity

    Expressed at low levels in several tissues including testis, ovary, and thymus.
  • Sequence similarities

    Belongs to the C5-methyltransferase family.
    Contains 1 ADD-type zinc finger.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab180335 (3μg).

References

ab180335 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab180335.
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