Recombinant Human DPAGT1/GPT protein (ab158303)

Overview

  • Product name

    Recombinant Human DPAGT1/GPT protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      IIPCPRHRIPRLNIKTGKLEMSYSKFKTKSLSFLGTFILKVAESLQLVTV HQSETEDGEFTECNNMTLINLLLKVLGPIHER
    • Amino acids

      296 to 377
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.

    Previously labelled as DPAGT1. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • ALG7
    • AU021132
    • CDG Ij
    • CDG1J
    • CMS13
    • CMSTA2
    • D11S366
    • DGPT
    • Dolichyl phosphate (UDP N acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc 1 P transferase)
    • Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
    • DPAGT1
    • DPAGT2
    • G1PT
    • GlcNAc 1 P transferase 1
    • GlcNAc-1-P transferase
    • Gnpta
    • GPT
    • GPT_HUMAN
    • H2afx
    • N-acetylglucosamine-1-phosphate transferase
    • UAGT
    • UDP GlcNAc:dolichyl phosphate N acetylglucosaminephosphotransferase
    • UDP N acetylglucosamine dolichyl phosphate N acetylglucosaminephosphotransferase 1
    • UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
    • UGAT
    see all
  • Function

    Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.
  • Pathway

    Protein modification; protein glycosylation.
  • Involvement in disease

    Defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J (CDG1J) [MIM:608093]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similarities

    Belongs to the glycosyltransferase 4 family.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt

Images

  • ab158303 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158303 has not yet been referenced specifically in any publications.

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