Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Active: Yes
- Suitable for: Functional Studies, SDS-PAGE
Product nameRecombinant human DPP2 protein
Biological activitySpecific Activity: 1882 pmol/min/µg.
Expression systemBaculovirus infected Sf9 cells
Protein lengthProtein fragment
Amino acids26 to 492
Our Abpromise guarantee covers the use of ab79660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituents: 0.395% Tris HCl, 0.05% Tween, 10% Glycerol, 0.754% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Dipeptidyl aminopeptidase II
- Dipeptidyl peptidase 7
- Dipeptidyl peptidase II
RelevanceDPP2 is a serine protease found most abundantly in the lysosome. There is also a non-lysosomal membrane-associated form of DPP2 reported in the rat brain (DPP-II-M), and a soluble form (DPP-II-S). First discovered as an enzyme involved in the terminal steps of protein degradation, and later as an enzyme involved in cell growth and quiescence, DPP2 cleaves N-terminal dipeptides and tripeptides from proteins. DPP2 has a preference for proline in the P1 position, and processes the tripeptides generated by DPP1 (which is unable to cleave if proline is in the P1 position). Some tumor cell lines express elevated DPP2 levels, and serum levels of DPP2 are elevated in some cancer patients, making DPP2 a potential tumor marker. DPP2 levels have been also been reported to be elevated in the cerebral spinal fluid from Parkinson’s patients.
Cellular localizationLysosome. Cytoplasmic vesicle. Secreted.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab79660 has not yet been referenced specifically in any publications.