The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
dpy 19 like 2
dpy 19 like 2 (C. elegans)
Dpy 19 like protein 2
Dpy-19-like protein 2
Protein dpy 19 homolog 2
Protein dpy-19 homolog 2
Required during spermatogenesis for sperm head elongation and acrosome formation.
Widely expressed with high expression in testis. Not detectable in ejaculated sperm (at protein level).
Involvement in disease
Defects in DPY19L2 are a cause of globozoospermia (GLOBZOOS) [MIM:102530]. An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome. In the most severe cases the acrosome is totally absent. Globozoospermia is also characterized by abnormal nuclear shape as well as abnormal arrangement of the mitochondria of the spermatozoon. Note=Deletions in DPY19L2 are probably the major cause of GLOBZOOS.