Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      ASGTEAA AATPSKVWGS SAGRIEPRGG GRGALPTSMG QHGPSARARA GRAPGPRPAR EASPRLRVHK TFKFVVVGVL LQVVPSSAAT IKLHDQSIGT QQWEHSPLGE LCPPGSHRSE HPGACNRCTE GVGYTNASNN LFACLPCTAC KSDEEERSPC TTTRNTACQC KPGTFRNDNS AEMCRKCSRG CPRGMVKVKD CTPWSDIECV HKESGNGHN
    • Molecular weight
      49 kDa including tags
    • Amino acids
      24 to 239
    • Additional sequence information
      Extracellular domain.This protein carries a human IgG1 Fc tag at the C-terminus (NP_003835).

Associated products

Specifications

Our Abpromise guarantee covers the use of ab220558 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    >95% by SDS-PAGE .

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -80°C. Avoid freeze / thaw cycle. Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C..

    pH: 7.50
    Constituents: 0.61% Tris, 0.75% Glycine, 5% Trehalose

    Lyophilized from 0.22 µm filtered solution.

General Info

  • Alternative names
    • Apo2
    • CD261
    • Cytotoxic TRAIL receptor
    • Death receptor 4
    • DR4
    • NF related apoptosis-inducing ligand receptor 1
    • TNF receptor superfamily member 10a
    • TNF-related apoptosis-inducing ligand receptor 1
    • TNFRSF10A
    • TR10A_HUMAN
    • TRAIL receptor 1
    • TRAIL-R1
    • TRAILR 1
    • TRAILR1
    • Tumor necrosis factor receptor superfamily member 10A
    • Tumor necrosis factor receptor superfamily member 10a variant 2
    • Tumor necrosis factor receptor superfamily, member 10a
    see all
  • Function
    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
  • Tissue specificity
    Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
  • Sequence similarities
    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE analysis of reduced ab220558 stained overnight with Coomassie Blue.

    The protein migrates as 47-49 kDa under reducing condition (SDS-PAGE) due to glycosylation.

References

ab220558 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab220558.
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