The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Measured by its binding ability in a functional ELISA. Immobilized ab174009 at 10 μg/ml (100 μl/well ) can bind biotinylated TNFSF10 with a linear range of 2.0 - 35 ng/ml.
< 1.000 Eu/µg
>95% by SDS-PAGE .
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -20°C or -80°C.
Information available upon request.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
It is recommended to reconstitute the lyophilized protein in 100 µl sterile deionized water to a final concentration of 1 mg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage
Fas like protein
Apoptosis inducing protein TRICK2A/2B
Apoptosis inducing receptor TRAIL R2
Cytotoxic TRAIL receptor 2
Death domain containing receptor for TRAIL/Apo 2L
Death receptor 5
p53 regulated DNA damage inducible cell death receptor(killer)
TNF related apoptosis inducing ligand receptor 2
TNF-related apoptosis-inducing ligand receptor 2
TRAIL receptor 2
Tumor necrosis factor receptor like protein ZTNFR9
Tumor necrosis factor receptor superfamily member 10B
Tumor necrosis factor receptor superfamily, member 10b
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Involvement in disease
Squamous cell carcinoma of the head and neck
Contains 1 death domain. Contains 3 TNFR-Cys repeats.