Recombinant Human DUSP26 protein (denatured) (ab171697)

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Overview

  • Product name
    Recombinant Human DUSP26 protein (denatured)
  • Protein length
    Full length protein
  • Description
    Recombinant Human DUSP26 protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      Q9BV47
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA
    • Molecular weight
      26 kDa
    • Amino acids
      1 to 211
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab171697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 85 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • DSP-4
    • Dual specificity phosphatase 26
    • Dual specificity phosphatase 26 (putative)
    • Dual specificity phosphatase SKRP3
    • Dual specificity protein phosphatase 26
    • DUS26_HUMAN
    • DUSP24
    • DUSP26
    • Hypothetical protein FLJ31142
    • LDP 4
    • LDP-4
    • Low molecular mass dual specificity phosphatase 4
    • Low-molecular-mass dual-specificity phosphatase 4
    • MAP kinase phosphatase 8
    • MGC1136
    • MGC2627
    • Mitogen activated protein kinase phosphatase 8
    • Mitogen-activated protein kinase phosphatase 8
    • MKP-8
    • MKP8
    • NATA1
    • NATA1 protein
    • Novel amplified gene in thyroid anaplastic cancer
    • SKRP3
    see all
  • Function
    Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
  • Tissue specificity
    Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Cellular localization
    Cytoplasm. Nucleus. Golgi apparatus.
  • Information by UniProt

Images

  • SDS-PAGE - DUSP26 protein (His tag) (ab171697)
    SDS-PAGE - DUSP26 protein (His tag) (ab171697)
    15% SDS-PAGE analysis of ab171697 (3 µg).

References

ab171697 has not yet been referenced specifically in any publications.

Publishing research using ab171697? Please let us know so that we can cite the reference in this datasheet.

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