The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 8.00 Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol
Dual specificity phosphatase 26
Dual specificity phosphatase 26 (putative)
Dual specificity phosphatase SKRP3
Dual specificity protein phosphatase 26
Hypothetical protein FLJ31142
Low molecular mass dual specificity phosphatase 4
Low-molecular-mass dual-specificity phosphatase 4
MAP kinase phosphatase 8
Mitogen activated protein kinase phosphatase 8
Mitogen-activated protein kinase phosphatase 8
Novel amplified gene in thyroid anaplastic cancer
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.