Recombinant Human DUSP26 protein (denatured) (ab171697)

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Description

  • Product name

    Recombinant Human DUSP26 protein (denatured)

  • Purity

    > 85 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    Q9BV47

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA

    • Predicted molecular weight

      26 kDa

    • Amino acids

      1 to 211

    • Tags

      His tag N-Terminus

  • Description

    Recombinant Human DUSP26 protein

Specifications

Our Abpromise guarantee covers the use of ab171697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • DSP-4
    • Dual specificity phosphatase 26
    • Dual specificity phosphatase 26 (putative)
    • Dual specificity phosphatase SKRP3
    • Dual specificity protein phosphatase 26
    • DUS26_HUMAN
    • DUSP24
    • DUSP26
    • Hypothetical protein FLJ31142
    • LDP 4
    • LDP-4
    • Low molecular mass dual specificity phosphatase 4
    • Low-molecular-mass dual-specificity phosphatase 4
    • MAP kinase phosphatase 8
    • MGC1136
    • MGC2627
    • Mitogen activated protein kinase phosphatase 8
    • Mitogen-activated protein kinase phosphatase 8
    • MKP-8
    • MKP8
    • NATA1
    • NATA1 protein
    • Novel amplified gene in thyroid anaplastic cancer
    • SKRP3
    see all

  • Function

    Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).

  • Tissue specificity

    Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.

  • Sequence similarities

    Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
    Contains 1 tyrosine-protein phosphatase domain.

  • Cellular localization

    Cytoplasm. Nucleus. Golgi apparatus.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human DUSP26 protein (denatured) (ab171697)
    SDS-PAGE - Recombinant Human DUSP26 protein (denatured) (ab171697)
    15% SDS-PAGE analysis of ab171697 (3 µg).

References

ab171697 has not yet been referenced specifically in any publications.

Publishing research using ab171697? Please let us know so that we can cite the reference in this datasheet.

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