Overview

  • Product name

    Recombinant Human Dynein intermediate chain 1/DNAI1 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MIPASAKSPHKQPHKQSISIGRGTRKRDEDSGTEVGEGTDEWAQSKATVR PPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQL AVHYTQVGNLIPKDSDEGRRQHYRDELVAGSQESVKVISETGNLEEDEEP KELETEPGSQTDVPAAGAAEKVTEEELMTPKQPKERKLTNQFNFSERASQ TCNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEKQEKTKEKEKA KTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDDIAQ DFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAV GYGSYDFMKQSRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVA VGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLN FFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHQVGCGT AFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNP YHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAA VTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDR GHIISLKLSPNLRKMPKEKKGQEVQKGPAVEIAKLDKLLNLVREVKIKT
    • Amino acids

      1 to 699
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153279 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.

     This product was previously labelled as Dynein intermediate chain 1

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Axonemal dynein intermediate chain 1
    • Axonemal dynein intermediate chain 2
    • CILD 1
    • CILD1
    • Cytoplasmic dynein 1 intermediate chain 1
    • Cytoplasmic dynein 1 intermediate chain 2
    • Cytoplasmic dynein intermediate chain 1
    • Cytoplasmic dynein intermediate chain 2
    • DH IC 1
    • DH IC 2
    • DIC1
    • DNAI 1
    • DNAI 2
    • DNAI1
    • DNAI1_HUMAN
    • DNAI2
    • DNCI 2
    • DNCI1
    • DNCI2
    • DNCIC 1
    • DNCIC 2
    • DNCIC1
    • DNCIC2
    • Dynein axonemal intermediate chain 1
    • Dynein axonemal intermediate polypeptide 1
    • Dynein axonemal intermediate polypeptide 2
    • Dynein cytoplasmic intermediate polypeptide 1
    • Dynein cytoplasmic intermediate polypeptide 2
    • Dynein intermediate chain 1 axonemal
    • Dynein intermediate chain 1 cytosolic
    • Dynein intermediate chain 1, axonemal
    • Dynein intermediate chain 2 axonemal
    • Dynein intermediate chain 2 cytosolic
    • Dynein intermediate chain DNAI1
    • IC74
    • ICS
    • ICS1
    • Immotile cilia syndrome 1
    • MGC26204
    • PCD
    see all
  • Function

    Part of the dynein complex of respiratory cilia.
  • Involvement in disease

    Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1) [MIM:244400]. CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
    Defects in DNAI1 are the cause of Kartagener syndrome (KTGS) [MIM:244400]. KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera).
  • Sequence similarities

    Belongs to the dynein intermediate chain family.
    Contains 5 WD repeats.
  • Cellular localization

    Cytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt

Images

  • ab153279 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

This product has been referenced in:

  • Calderilla-Barbosa L  et al. Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking. J Cell Sci 127:4052-63 (2014). Read more (PubMed: 25015291) »
See 1 Publication for this product

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