The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Axonemal dynein intermediate chain 2
Dynein axonemal intermediate chain 2
Dynein axonemal intermediate polypeptide 2
Dynein intermediate chain 2
Dynein intermediate chain 2 axonemal
Part of the dynein complex of respiratory cilia.
Highly expressed in trachea and testis.
Involvement in disease
Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
Belongs to the dynein intermediate chain family. Contains 5 WD repeats.
SDS-PAGE - Recombinant Human Dynein intermediate chain 2 protein (ab163843)
ab163843 on a 12.5% SDS-PAGE stained with Coomassie Blue.
This product has been referenced in:
Calderilla-Barbosa L et al. Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking. J Cell Sci127:4052-63 (2014).
Read more (PubMed: 25015291) »