Description

  • Product name

    Recombinant Human DYRK1A protein (denatured)
    See all DYRK1A proteins and peptides
  • Purity

    > 80 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHHSSGLVPRGSHRSYEIDSLIGKGSFGQVVKAYDRVEQEWVA IKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCL VFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHC DLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILD QAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGG RRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
    • Predicted molecular weight

      39 kDa including tags
    • Amino acids

      159 to 479
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NCBI Accession No. NP_036923.
  • Description

    Recombinant Human DYRK1A protein

Specifications

Our Abpromise guarantee covers the use of ab181940 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8
    Constituents: 0.32% Tris HCl, 10% Glycerol, 2.4% Urea

General Info

  • Alternative names

    • Dual specificity tyrosine phosphorylation regulated kinase
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A
    • Dual specificity tyrosine phosphorylation regulated kinase 1
    • Dual specificity tyrosine phosphorylation regulated kinase 1A
    • Dual specificity tyrosine-phosphorylation-regulated kinase 1A
    • Dual specificity YAK 1 related kinase
    • Dual specificity YAK1 related kinase
    • Dual specificity YAK1-related kinase
    • DYR1A_HUMAN
    • DYRK
    • DYRK 1
    • DYRK 1A
    • DYRK1
    • Dyrk1a
    • DYRKA
    • hMNB
    • HP 86
    • HP86
    • Minibrain (Drosophila) homolog
    • Minibrain homolog
    • Minibrain, Drosophila, homolog of
    • MNB
    • MNB protein kinase
    • Mnb protein kinase homolog hp86
    • MNB protein kinase, Serine/threonine-specific
    • MNB/DYRK protein kinase
    • MNBH
    • MRD7
    • OTTHUMP00000109090
    • OTTHUMP00000109091
    • OTTHUMP00000109094
    • OTTHUMP00000174799
    • Protein kinase minibrain homolog
    • Serine/threonine kinase MNB
    see all
  • Function

    May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
  • Tissue specificity

    Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
  • Involvement in disease

    Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • Developmental stage

    Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.
  • Domain

    The polyhistidine repeats act as targeting signals to nuclear speckles (PubMed:19266028).
  • Post-translational
    modifications

    Autophosphorylated on tyrosine residues.
  • Cellular localization

    Nucleus speckle.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab181940 (3μg).

References

ab181940 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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