Description

  • Product name

    Recombinant human DYRK2 protein
    See all DYRK2 proteins and peptides
  • Biological activity

    The specific activity of ab133138 was determined to be 1250 nmol/min/mg.
  • Purity

    > 75 % Densitometry.

  • Expression system

    Baculovirus infected Sf9 cells
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      67 kDa
    • Amino acids

      1 to 601

Associated products

Specifications

Our Abpromise guarantee covers the use of ab133138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    Functional Studies

  • Form

    Liquid
  • Additional notes

    ab204857 (DYRKtide peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.005% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • 1810038L18Rik
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 2
    • Dual specificity tyrosine phosphorylation regulated kinase 2
    • Dual specificity tyrosine-phosphorylation-regulated kinase 2
    • DYRK2
    • DYRK2_HUMAN
    • EC 2.7.12.1
    • FLJ21217
    • FLJ21365
    see all
  • Function

    Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
  • Tissue specificity

    Testis, after the onset of spermatogenesis.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Phosphorylated on serine/threonine residues.
  • Cellular localization

    Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
  • Information by UniProt

Images

  • The specific activity of DYRK2 (ab133138) was determined to be 1100 nmol/min/mg as per activity assay protocol
  • SDS PAGE analysis of ab133138
  • SDS PAGE analysis of ab133138
  • SDS-PAGE analysis of ab133138.
  • The specific activity of ab133138 was determined to be 1250 nmol/min/mg.

References

ab133138 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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