• Product name

    Recombinant human Dystrophia myotonica protein kinase / DMPK
  • Biological activity

    The Specific activity of ab85755 was determined to be 4.5 nmol/min/mg.
  • Expression system

    Baculovirus infected Sf9 cells
  • Protein length

    Full length protein
  • Animal free

  • Nature

    • Species


Associated products


Our Abpromise guarantee covers the use of ab85755 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Functional Studies


  • Form

  • Additional notes

    ab204853 (IRS1 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.0038% EGTA, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • DM
    • DM 1
    • DM kinase
    • DM protein kinase
    • DM-kinase
    • DM1
    • DM1 protein kinase
    • DM1PK
    • DMK
    • DMPK
    • Dystrophia myotonica 1
    • Dystrophia myotonica protein kinase
    • MDPK
    • MT PK
    • MT-PK
    • Myotonic dystrophy associated protein kinase
    • Myotonic dystrophy protein kinase
    • Myotonin protein kinase
    • Myotonin protein kinase A
    • Myotonin-protein kinase
    • Thymopoietin homolog
    see all
  • Function

    Critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.
  • Tissue specificity

    Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
  • Involvement in disease

    Defects in DMPK are the cause of dystrophia myotonica type 1 (DM1) [MIM:160900]; also known as Steinert disease. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.
  • Sequence similarities

    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
  • Information by UniProt


  • The specific activity of Dystrophia myotonica protein kinase / DMPK (ab85755) was determined to be 5.2 nmol/min/mg as per activity assay protocol
  • SDS PAGE analysis of ab85755
  • SDS PAGE analysis of ab85755
  • The specific activity of ab85755 was determined to be 4.5 nmol/min/mg.

  • SDS-PAGE showing ab85755 at approximately 105kDa.


ab85755 has not yet been referenced specifically in any publications.

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