Recombinant Human E2F8 protein (ab153513)

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Overview

  • Product name

    Recombinant Human E2F8 protein

  • Protein length

    Full length protein

Description

  • Nature

    Recombinant

  • Source

    Wheat germ
  • Amino Acid Sequence

    • Species

      Human

    • Sequence

      MAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVNAEMELT APSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTP PQGLSPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAP ERQGAKSRTREPAGERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPS GYLIPLTQCSSLGAESILSGKENSSALSPNHRIYSSPIAGVIPVTSSELT AVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALASSHPVPIQNPSSAIVNF TLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQGRATNYD SPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSS SCMDFEGANKTSLGTLFVPQRKLEVSTEDVH

    • Amino acids

      1 to 431

    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153513 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid

  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • E2F 8
    • E2F family member 82
    • E2F transcription factor 8
    • E2F-8
    • E2f8
    • E2F8_HUMAN
    • FLJ23311
    • Transcription factor E2F8
    see all

  • Function

    Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.

  • Sequence similarities

    Belongs to the E2F/DP family.

  • Domain

    Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer.

  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human E2F8 protein (ab153513)
    SDS-PAGE - Recombinant Human E2F8 protein (ab153513)
    ab153513 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153513 has not yet been referenced specifically in any publications.

Publishing research using ab153513? Please let us know so that we can cite the reference in this datasheet.

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