The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
>95% by SDS-PAGE .
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C.
Constituent: 50% Glycerol Note: Buffered with PBS or Tris.
EBV induced gene 3 protein
EBV-induced gene 3 protein
Epstein Barr virus induced 3
Epstein Barr virus induced gene 3
Epstein Barr virus induced gene 3 protein
Epstein-Barr virus-induced gene 3 protein
IL 27 subunit beta
IL-27 subunit beta
IL27 subunit beta
interleukin 27 subunit beta
Interleukin-27 subunit beta
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 2 fibronectin type-III domains.