Recombinant Human EBP1 protein (ab95350)

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Description

  • Product name

    Recombinant Human EBP1 protein

  • Purity

    > 95 % SDS-PAGE.
    ab95350 is purified using conventional chromatography techniques.

  • Expression system

    Escherichia coli

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN VAHTFVVDVA QGTQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS SASRKTQKKK KKKASKTAEN ATSGETLEEN EAGDLEHHHH HH

Specifications

Our Abpromise guarantee covers the use of ab95350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.316% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • 38kDa
    • AA672939
    • Cell cycle protein p38 2G4 homolog
    • Cell cycle protein p38-2G4 homolog
    • ErbB-3 binding protein 1
    • ErbB3 binding protein 1
    • ErbB3-binding protein 1
    • ErbB3-binding protein Ebp1
    • hG4 1
    • hG4-1
    • IRES-specific cellular trans-acting factor 45 kDa
    • MGC81621
    • MGC94070
    • Mpp1
    • p38 2G4
    • Pa2g4
    • PA2G4_HUMAN
    • Plfap
    • Proliferation associated 2G4
    • Proliferation associated 2G4, 38-KD
    • Proliferation-associated 2G4, 38kDa
    • Proliferation-associated 2G4, a
    • Proliferation-associated protein 1
    • Proliferation-associated protein 2G4
    • Protein p38-2G4
    • si:dz150i12.2
    • wu:fb19b11
    • wu:ft56d05
    • zgc:86732
    see all

  • Function

    May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).

  • Tissue specificity

    Expressed in several cell lines tested, including primary and transformed cell lines.

  • Sequence similarities

    Belongs to the peptidase M24 family.

  • Post-translational
    modifications

    Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent.

  • Cellular localization

    Cytoplasm. Nucleus > nucleolus. Tranlocates to the nucleus upon treatment with HRG.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human EBP1 protein (ab95350)
    SDS-PAGE - Recombinant Human EBP1 protein (ab95350)
    15% SDS-PAGE showing ab95350 at approximately 45 kDa (3 µg).
  • Western blot - Recombinant Human EBP1 protein (ab95350)
    Western blot - Recombinant Human EBP1 protein (ab95350)

References

ab95350 has not yet been referenced specifically in any publications.

Publishing research using ab95350? Please let us know so that we can cite the reference in this datasheet.

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