Recombinant Human ECM protein (ab161476)
- Datasheet
- References
- Protocols
Description
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Product name
Recombinant Human ECM protein -
Expression system
Wheat germ -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
IHTNQAESHTAVGRGVAEQQQQQGCGDPEVMQKMTDQVNYQAMKLTLLQK KIDNISLTVNDVRNTYSSLEGKVSEDKSREFQSLLKGLKSKSINVLIRDI -
Amino acids
291 to 390 -
Tags
GST tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab161476 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
ELISA
Western blot
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Form
Liquid -
Additional notes
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- 155 kDa platelet multimerin
- ECM
- Elastin microfibril interface located protein 4
see all -
Function
Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. -
Tissue specificity
Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium of blood vessels. Not found in plasma. Found in vascular tissues such as placenta, lung, and liver. -
Involvement in disease
Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is associated with an autosomal dominant bleeding disorder (factor V Quebec). -
Sequence similarities
Contains 1 C1q domain.
Contains 1 EGF-like domain.
Contains 1 EMI domain. -
Post-translational
modificationsThe N-terminus is blocked.
Extensively N-glycosylated. -
Cellular localization
Secreted. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human ECM protein (ab161476)ab161476 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Datasheets and documents
References
ab161476 has not yet been referenced specifically in any publications.
