Description

  • Product name

    Recombinant Human EDARADD protein
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      14 kDa
    • Amino acids

      1 to 127
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • Cr
    • Crinkled homolog
    • ectodysplasia A receptor associated death domain
    • Ectodysplasin-A receptor-associated adapter protein
    • ED3
    • EDA3
    • EDAD_HUMAN
    • EDAR associated death domain
    • EDAR-associated death domain protein
    • EDARADD
    • Protein crinkled homolog
    see all
  • Function

    Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.
  • Tissue specificity

    Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis.
  • Involvement in disease

    Defects in EDARADD are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
  • Sequence similarities

    Contains 1 death domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt

References

ab127599 has not yet been referenced specifically in any publications.

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