Embryonic ectoderm development protein, mouse, homolog of
Polycomb protein eed
WD protein associating with integrin cytoplasmic tails 1
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.
Belongs to the WD repeat ESC family. Contains 7 WD repeats.
Expression peaks at the G1/S phase boundary.
Nucleus. Chromosome. Transiently colocalizes with XIST at inactive X chromosomes.