Description

  • Product name

    Recombinant Human EFEMP1/Fibulin-3 protein
  • Expression system

    Wheat germ
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVGQQCKDIDECDI VPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTG VVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIP SNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ CPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNY TCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMC WNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSI RSDRSVPSDIFQIQATTIYANTINTFRIKSGSENGEFYLRQTSPVSAMLV LVKSLSGPREHIVDLEMLTASSIGTFRTSSVLRLTIIVGPFSF
    • Predicted molecular weight

      80 kDa including tags
    • Amino acids

      1 to 493

Specifications

Our Abpromise guarantee covers the use of ab114651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.

     This product was previously labelled as EFEMP1

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • DHRD
    • Doyne honeycomb retinal degeneration
    • DRAD
    • EFEMP 1
    • EFEMP1
    • EGF containing fibulin like extracellular matrix protein 1
    • EGF containing fibulin like extracellular matrix protein 1 precursor
    • EGF-containing fibulin-like extracellular matrix protein 1
    • Epidermal growth factor containing fibulin like extracellular matrix protein 1
    • Extracellular protein S1 5
    • Extracellular protein S1-5
    • FBLN 3
    • FBLN3
    • FBLN3_HUMAN
    • FBNL
    • FIBL 3
    • FIBL-3
    • FIBL3
    • Fibrillin like
    • Fibrillin like protein
    • Fibrillin-like protein
    • FIBULIN 3
    • Fibulin-3
    • Fibulin3
    • FLJ35535
    • Heat shock 70 KD protein 1
    • MGC111353
    • MLVT
    • MTLV
    • S1 5
    • T16 protein
    see all
  • Function

    Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
  • Tissue specificity

    In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
  • Involvement in disease

    Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]; also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.
  • Sequence similarities

    Belongs to the fibulin family.
    Contains 6 EGF-like domains.
  • Cellular localization

    Secreted > extracellular space. Secreted > extracellular space > extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab114651 at approximately 79.97kDa stained with Coomassie Blue.

References

ab114651 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab114651.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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