Description

  • Product name

    Recombinant Human EIF2B5 protein
  • Expression system

    Wheat germ
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MAAPVVAPPGVVVSRANKRSGAGPGGSGGGGARGAEEEPPPPLQAVLVAD SFDRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAA QIKEHLLKSKWCRPTSLNVVRIITSELYRSLGDVLRDVDAKALVRSDFLL VYGDVISNINITRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDN VVVAVDSTTNRVLHFQKTQGLRRFAFPLSLFQGSSDGVEVRYDLLDCHIS ICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTAKEYGARV SNLHMYSAVCADVIRRWVYPLTPEANFTDSTTQSCTHSRHNIYRGPEVSL GHGSILEENVLLGSGTVIGSNCFITNSVIGPGCHIGDNVVLDQTYLWQGV RVAAGAQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPNITLPEGSVIS LHPPDAEEDEDDGEFSDDSGADQEKDKVKMKGYNPAEVGAAGKGYLWKAA GMNMEEEEELQQNLWGLKINMEEESESESEQSMDSEEPDSRGGSPQMDDI KVFQNEVLGTLQRGKEENISCDNLVLEINSLKYAYNVSLKEVMQVLSHVV LEFPLQQMDSPLDSSRYCALLLPLLKAWSPVFRNYIKRAADHLEALAAIE DFFLEHEALGISMAKVLMAFYQLEILAEETILSWFSQRDTTDKGQQLRKN QQLQRFIQWLKEAEEESSEDD
    • Predicted molecular weight

      107 kDa including tags
    • Amino acids

      1 to 721

Specifications

Our Abpromise guarantee covers the use of ab131963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.

     This product was previously labelled as eIF2B epsilon

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • CACH
    • CLE
    • EI2BE_HUMAN
    • EIF 2B
    • eIF 2B GDP GTP exchange factor
    • eIF 2B GDP GTP exchange factor subunit epsilon
    • eIF-2B GDP-GTP exchange factor subunit epsilon
    • EIF2B
    • EIF2B5
    • EIF2BE
    • EIF2Bepsilon
    • Eukaryotic Translation Initiation Factor 2 Beta Epsilon
    • Eukaryotic translation initiation factor 2B subunit 5 epsilon
    • Eukaryotic translation initiation factor 2B subunit 5 epsilon 82kDa
    • LVWM
    • Translation initiation factor eIF 2B subunit epsilon
    • Translation initiation factor eIF-2B subunit epsilon
    see all
  • Function

    Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
  • Involvement in disease

    Defects in EIF2B5 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
  • Sequence similarities

    Belongs to the eIF-2B gamma/epsilon subunits family.
    Contains 1 W2 domain.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab131963 stained with Coomassie Blue.

References

ab131963 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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