Overview

  • Product name
    Recombinant Human EIF3S2 protein (denatured)
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMKPILLQ GHERSITQIK YNREGDLLFT VAKDPIVNVW YSVNGERLGT YMGHTGAVWC VDADWDTKHV LTGSADNSCR LWDCETGKQL ALLKTNSAVR TCGFDFGGNI IMFSTDKQMG YQCFVSFFDL RDPSQIDNNE PYMKIPCNDS KITSAVWGPL GECIIAGHES GELNQYSAKS GEVLVNVKEH SRQINDIQLS RDMTMFVTAS KDNTAKLFDS TTLEHQKTFR TERPVNSAAL SPNYDHVVLG GGQEAMDVTT TSTRIGKFEA RFFHLAFEEE FGRVKGHFGP INSVAFHPDG KSYSSGGEDG YVRIHYFDPQ YFEFEFEA
    • Molecular weight
      39 kDa including tags
    • Amino acids
      1 to 325
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab171491 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    >90% by SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • eIF-3-beta
    • eIF3 beta
    • eIF3 p36
    • eIF3-beta
    • eIF3-p36
    • eIF3i
    • EIF3I_HUMAN
    • EIF3S2
    • EIF3S2, formerly
    • Eukaryotic translation initiation factor 3 subunit 2
    • Eukaryotic translation initiation factor 3 subunit 2 beta
    • Eukaryotic translation initiation factor 3 subunit I
    • eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD
    • eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa
    • eukaryotic translation initiation factor 3, subunit 2, formerly
    • eukaryotic translation initiation factor 3, subunit I
    • Predicted protein of HQ2242
    • PRO2242
    • TGF beta receptor interacting protein 1
    • TGF-beta receptor-interacting protein 1
    • TGFbeta receptor interacting protein 1
    • TGFbeta receptor-interacting protein 1
    • TRIP 1
    • TRIP-1
    • TRIP1
    see all
  • Function
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
  • Sequence similarities
    Belongs to the eIF-3 subunit I family.
    Contains 5 WD repeats.
  • Post-translational
    modifications
    Phosphorylated by TGF-beta type II receptor.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3µg ab171491.

References

ab171491 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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