Eukaryotic translation initiation factor 4E like 1
Messanger RNA Cap Binding Protein eIF 4E
mRNA cap binding protein
mRNA cap-binding protein
Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
Belongs to the eukaryotic initiation factor 4E family.
Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.