Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQ IHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNT VPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAK PSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKA GDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGL RKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYL HLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQL LCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVP MGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWK EFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEG SSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVL KARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDV VKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
    • Amino acids
      1 to 645
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • DKFZp686A1451
    • eIF 4 gamma 1
    • eIF 4G 1
    • eIF 4G1
    • eIF-4-gamma 1
    • eIF-4G 1
    • eIF-4G1
    • EIF4 gamma
    • EIF4F
    • EIF4G
    • EIF4G1
    • EIF4GI
    • Eukaryotic translation initiation factor 4 gamma 1
    • IF4G1_HUMAN
    • p220
    see all
  • Function
    Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
  • Involvement in disease
    Defects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:614251]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
  • Sequence similarities
    Belongs to the eIF4G family.
    Contains 1 MI domain.
    Contains 1 MIF4G domain.
    Contains 1 W2 domain.
  • Post-translational
    modifications
    Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.
    Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
  • Information by UniProt

Images

  • ab158341 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158341 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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