Product nameRecombinant Human eIF4G1 protein
See all eIF4G1 proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQ IHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNT VPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAK PSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKA GDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGL RKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYL HLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQL LCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVP MGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWK EFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEG SSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVL KARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDV VKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Amino acids1 to 645
Tagsproprietary tag N-Terminus
Our Abpromise guarantee covers the use of ab158341 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.31% Glutathione, 0.79% Tris HCl
- eIF 4 gamma 1
- eIF 4G 1
FunctionComponent of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
Involvement in diseaseDefects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:614251]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
Sequence similaritiesBelongs to the eIF4G family.
Contains 1 MI domain.
Contains 1 MIF4G domain.
Contains 1 W2 domain.
modificationsPhosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.
Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
- Information by UniProt
ab158341 has not yet been referenced specifically in any publications.