Overview

  • Product name

    Recombinant Human eIF4H protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMADFDT YDDRAYSSFG GGRGSRGSAG GHGSRSQKEL PTEPPYTAYV GNLPFNTVQG DIDAIFKDLS IRSVRLVRDK DTDKFKGFCY VEFDEVDSLK EALTYDGALL GDRSLRVDIA EGRKQDKGGF GFRKGGPDDR GMGSSRESRG GWDSRDDFNS GFRDDFLGGR GGSRPGDRRT GPPMGSRFRD GPPLRGSNMD FREPTEEERA QRPRLQLKPR TVATPLNQVA NPNSAIFGGA RPREEVVQKE QE
    • Molecular weight

      30 kDa including tags
    • Amino acids

      1 to 248
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab126684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 90 % SDS-PAGE.
    ab126684 is purified using conventional chromatography techniques.
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.03% DTT, 0.32% Tris HCl, 50% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names

    • AU018978
    • D5Ertd355e
    • E430026L18Rik
    • Ef4h
    • eIF 4H
    • eIF-4H
    • EIF4H
    • Eukaryotic translation initiation factor 4H
    • IF4H_HUMAN
    • KIAA0038
    • WBSCR1
    • Williams Beuren syndrome chromosomal region 1 protein homolog
    • Williams Beuren syndrome chromosome region 1
    • Williams-Beuren syndrome chromosomal region 1 protein
    • Williams-Beuren syndrome chromosome region 1
    • WSCR1
    see all
  • Function

    Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
  • Tissue specificity

    The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.
  • Involvement in disease

    Note=EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • Sequence similarities

    Contains 1 RRM (RNA recognition motif) domain.
  • Cellular localization

    Cytoplasm > perinuclear region.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab126684 (3 µg).

References

ab126684 has not yet been referenced specifically in any publications.

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