Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHS ASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDD EIEEMTETKETEESVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVH REDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVE KMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIIST FLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGA SLEKRWKFCGFEGLKLT
    • Amino acids
      1 to 317
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab161022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.

    Previously labelled as ENOX2. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • APK1
    • APK1 antigen
    • COVA1
    • Cytosolic ovarian carcinoma antigen 1
    • Ecto NOX disulfide thiol exchanger 2
    • ENOX 2
    • ENOX2
    • ENOX2_HUMAN
    • OTTHUMP00000024021
    • OTTHUMP00000024022
    • Protein disulfide-thiol oxidoreductase
    • tNOX
    • Tumor associated hydroquinone oxidase
    • Tumor-associated hydroquinone oxidase
    see all
  • Function
    May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
  • Tissue specificity
    Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.
  • Sequence similarities
    Belongs to the ENOX family.
    Contains 1 RRM (RNA recognition motif) domain.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Cell membrane. Secreted > extracellular space. Extracellular and plasma membrane-associated.
  • Information by UniProt

Images

  • ab161022 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab161022 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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