Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHS ASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDD EIEEMTETKETEESVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVH REDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVE KMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIIST FLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGA SLEKRWKFCGFEGLKLT
    • Amino acids

      1 to 317
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab161022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.

    Previously labelled as ENOX2. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • APK1
    • APK1 antigen
    • COVA1
    • Cytosolic ovarian carcinoma antigen 1
    • Ecto NOX disulfide thiol exchanger 2
    • ENOX 2
    • ENOX2
    • ENOX2_HUMAN
    • OTTHUMP00000024021
    • OTTHUMP00000024022
    • Protein disulfide-thiol oxidoreductase
    • tNOX
    • Tumor associated hydroquinone oxidase
    • Tumor-associated hydroquinone oxidase
    see all
  • Function

    May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
  • Tissue specificity

    Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.
  • Sequence similarities

    Belongs to the ENOX family.
    Contains 1 RRM (RNA recognition motif) domain.
  • Post-translational
    modifications

    Glycosylated.
  • Cellular localization

    Cell membrane. Secreted > extracellular space. Extracellular and plasma membrane-associated.
  • Information by UniProt

Images

  • ab161022 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab161022 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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