Description

  • Product name

    Recombinant Human ENOX2/tNOX protein (Tagged)
  • Purity

    > 85 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMA PLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEI IHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQ CGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRL HVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDH ECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDH FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETK ETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNK EQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLK EKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPF GASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK FCGFEGLKLT
    • Predicted molecular weight

      77 kDa including tags
    • Amino acids

      1 to 610
    • Additional sequence information

      N-terminal 10xHis-tagged and C-terminal Myc-tagged.

Specifications

Our Abpromise guarantee covers the use of ab235678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    Previously labelled as ENOX2. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Constituents: Tris buffer, 50% Glycerol

General Info

  • Alternative names

    • APK1
    • APK1 antigen
    • COVA1
    • Cytosolic ovarian carcinoma antigen 1
    • Ecto NOX disulfide thiol exchanger 2
    • ENOX 2
    • ENOX2
    • ENOX2_HUMAN
    • OTTHUMP00000024021
    • OTTHUMP00000024022
    • Protein disulfide-thiol oxidoreductase
    • tNOX
    • Tumor associated hydroquinone oxidase
    • Tumor-associated hydroquinone oxidase
    see all
  • Function

    May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
  • Tissue specificity

    Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.
  • Sequence similarities

    Belongs to the ENOX family.
    Contains 1 RRM (RNA recognition motif) domain.
  • Post-translational
    modifications

    Glycosylated.
  • Cellular localization

    Cell membrane. Secreted > extracellular space. Extracellular and plasma membrane-associated.
  • Information by UniProt

Images

  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel of ab235678.

References

ab235678 has not yet been referenced specifically in any publications.

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